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Unveiling the Hidden Power of 11-hydroxy-THC: An Inside Look at the Metabolism of THC

Decoding 11-hydroxy-THC The Hidden Powerhouse Behind THC Metabolism - KansasKratom

When you consume products that have Delta-8 THC or Delta-9 THC, your liver processes the THC and turns it into 11-hydroxy-THC. This compound, which is also called 11-OH-THC, is the main active form of THC once it’s absorbed.

11-hydroxy THC is similar to THC in terms of effects, but it kicks in faster because it doesn’t have to be processed by the liver in order to be turned from THC into 11-Hydroxy like most cannabinoids. However, our bodies don’t absorb it very well, and it’s hard to keep it stable without using solvents so there are some challenges to overcome.

What exactly is 11-hydroxy-THC?

THCA, a chemical found in raw cannabis, turns into THC when the plant ages or undergoes decarboxylation when it is heated. When you consume THC, your liver breaks it down into 11-hydroxy-THC and then 11-nor-9-carboxy-THC. Eating THC-infused edibles increases the amount of 11-hydroxy-THC in your bloodstream because of how your liver processes it. This liver process is helped along by an enzyme called CYP2C9. Funny enough, even though less THC circulates in your body when you eat cannabis, a higher percentage gets converted into 11-hydroxy-THC. That’s why orally consumed THC can feel stronger, even in smaller doses, compared to inhaling THC.

When you vape or smoke THC, it goes straight into your bloodstream from your lungs, without going through the liver and losing some of its potency to become 11-hydroxy-THC.

The Effects of 11-hydroxy-THC on Your Body

11-hydroxy-THC is thought to be about 2-3 times stronger than regular THC, so it can give you a deceptively strong effect despite the low milligram on the label. When you eat THC instead of smoking it, it takes longer to kick in, usually around 1-2 hours. Unfortunately there’s not a lot of research on how 11-hydroxy THC affects the body yet, so be aware that if you’re not used to THC, the effects might be really intense.

Casual Tips for Not Going Overboard on 11-hydroxy-THC

To avoid going overboard with THC, take it slow. Start with 15 to 35 mg and wait a couple of hours to see how it affects you. If needed, you can have an additional 15+ mg. Just remember, you can always take more, but you can’t take less. Don’t give in to the temptation of consuming all the edibles at once, as thinking they’re not working may result in going overboard, many people have way too far from doing that. To ensure safety, keep some non-cannabis snacks nearby, preferably something healthy. For best results eat a meal beforehand to ensure a healthy metabolism and good digestion.

Frequently Asked Questions

What’s the deal with people saying that the effect from taking edibles is totally unique?

Consuming edibles offers a distinct experience compared to inhaling cannabis. This is due to the process in which THC travels through the digestive system and liver, resulting in a higher conversion rate of THC to the potent 11-hydroxy-THC (11-OH-THC), which possesses enhanced properties. Decarboxylated cannabis, when consumed orally, often yields a more intense impact than inhalation. Additionally, the effects of edibles tend to have a prolonged duration.

Why don’t cannabis edibles seem to do anything for me?

THC affects people differently based on their metabolism and genetic variations in liver enzymes like cytochrome P450. Things like diet, recent food intake, body-mass index (BMI), individual tolerance, and activity levels can all play a role in how edibles affect you. Other cannabinoids and terpenes, like CBD and beta-caryophyllene, might also make a difference in your personal experience with THC.


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